BIO 004 · Human Anatomy

The Autonomic Nervous System

Block 5 · Module 6: The Autonomic Nervous System

A reference for the autonomic nervous system video and lab. This page covers the difference between the somatic and autonomic systems, the two-neuron motor pathway, the named autonomic ganglia, the sympathetic and parasympathetic divisions, and the autonomic and enteric plexuses. The focus is on the structures and the job each one does.

How to use this sheet Toggle the toolbar above. Notes prints the full reference for review. Study prints as a fill-in-the-blank worksheet. Print it, then write each definition while you watch the video or read your book. Quiz me is on-screen typing practice: type the term, click Reveal to check yourself. The comparison grids respond to Study and Quiz too, with a Reveal button on each row.

Practice Spaced Recall

The Foundations video gives you a complete foundational understanding of this topic, enough on its own for a foundational course. Learn it first, then move on to the Deep dive, which adds the majors-level depth for this course.


By the end
  1. Contrast the somatic and autonomic motor systems.
  2. Describe the two-neuron motor pathway and name the autonomic ganglia.
  3. Compare the sympathetic and parasympathetic divisions and the plexuses.

Your pre-work

Work through these the evening before class. None of it is turned in. It is how you learn the material and build your spaced recall.

This is more than a checklist. Ticking these boxes is the start, not the finish. Committing this material to memory and being able to apply it takes considerable time and repeated effort. You are not done when the boxes are checked. Put in the real hours, and keep coming back for frequent recall and review until the material is genuinely yours.

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The two divisions

Add a diagram contrasting the sympathetic and parasympathetic outflow from the CNS.

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The two-neuron pathway

Add a labeled view of the preganglionic neuron, the ganglion, and the postganglionic neuron.

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The autonomic ganglia

Add a view showing the sympathetic trunk, the prevertebral ganglia, and the terminal ganglia.


The Autonomic Nervous System, an Overview

The autonomic nervous system is the involuntary motor division. It quietly regulates the organs, adjusting them without conscious effort or awareness.


Somatic Versus Autonomic

The somatic and autonomic systems are both motor, but they differ in what they control, how many neurons they use, and what effect they have. Compare them.

The somatic and autonomic motor systems compared
FeatureSomatic nervous systemAutonomic nervous system
Effectorskeletal musclecardiac muscle, smooth muscle, and glands
Controlvoluntaryinvoluntary
Motor neurons in the pathwayone, from the CNS straight to the muscletwo, with a synapse in a ganglion
Effect on the effectoralways excitation; it causes contractioneither excitation or inhibition
Awarenessnormally consciousnormally not conscious

The Two-Neuron Motor Pathway

Where the somatic system reaches its muscle with a single neuron, the autonomic system always uses two neurons in a row, with a synapse in a ganglion between them.


The Autonomic Ganglia

The autonomic ganglia fall into two groups by division. The sympathetic ganglia sit close to the spinal cord; the parasympathetic ganglia sit close to or within the organ.

Sympathetic ganglia

Parasympathetic ganglia


The Two Divisions

The two divisions are told apart first by where they leave the CNS, and then by the work they do.

The sympathetic division

The parasympathetic division


Comparing the Two Divisions

Side by side, the two divisions differ in their origin in the CNS, the location of their ganglia, and their overall job. Compare them.

The sympathetic and parasympathetic divisions compared
FeatureSympatheticParasympathetic
Other namethoracolumbar divisioncraniosacral division
Origin in the CNSthe T1 to L2 spinal segmentsthe brainstem and the S2 to S4 spinal segments
Location of gangliaclose to the spinal cordclose to or within the effector organ
Overall rolefight or flight; prepares the body for actionrest and digest; conserves energy

The Autonomic and Enteric Plexuses

Autonomic axons and ganglia travel together in networks called plexuses. A separate set of networks, the enteric plexuses, runs the wall of the gut.

Autonomic plexuses

Enteric plexuses


Tracing an Autonomic Pathway

Every autonomic motor command travels the same four-step route from the central nervous system to the organ.

  1. Preganglionic neuronthe cell body in the brain or cord sends its axon out toward a ganglion
  2. Autonomic ganglionthe preganglionic axon synapses here with the postganglionic neuron
  3. Postganglionic neuronits axon carries the signal the rest of the way out
  4. Effector tissuethe cardiac muscle, smooth muscle, or gland receives the command

See also: The Peripheral Nervous System for the nerves these fibers travel in, and Functional Organization and Nervous Tissue for the neurons themselves. This is the final page of Block 5.

Study questions

Work on answering these in writing, in your own words. They are the questions to bring to class, and good practice for the reasoning the exams ask for.

  1. Compare the sympathetic and parasympathetic divisions by where their fibers leave the central nervous system.
  2. For one organ, describe what the sympathetic and parasympathetic inputs each do, and why rest-and-digest versus fight-or-flight captures the difference.
  3. Trace a two-neuron autonomic pathway from the CNS to an effector, naming the ganglion where the synapse occurs.
  4. Why is the adrenal medulla described as a modified sympathetic ganglion?
Dr. Sharilyn Rennie BIO 004 · Block 5 · Module 6