BIO 304 · Week 1 · Interactive Workbook

Cell Structure & Organelles

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Part 1 of 4 · Recall

Fill in the blanks

Type the term that completes each statement, using the word bank. Pull it from memory first.

Word bank

Phospholipid bilayerIntegral proteinsPeripheral proteinsGlycoproteins / glycolipidsNuclear envelopeChromatinNucleolusRough ER (RER)Smooth ER (SER)Golgi apparatusLysosomePeroxisomeMicrotubulesIntermediate filaments

  1. two layers of phospholipids; hydrophilic heads out, hydrophobic tails in
  2. span the membrane; channels, carriers, receptors
  3. attach to one side; signaling and structure
  4. sugar tags on the outer surface; cell-cell ID
  5. double membrane with pores; separates DNA from cytoplasm
  6. DNA + histone proteins; decondensed working state
  7. dark spot inside nucleus; builds ribosomal subunits
  8. studded with ribosomes; makes membrane and secreted proteins
  9. lipid & steroid synthesis; calcium storage in muscle
  10. modifies, sorts, packages proteins for delivery
  11. acidic digestive vesicle; recycles cell components
  12. breaks down fatty acids and detoxifies (esp. in liver)
  13. tubulin; tracks for transport, spindle in division
  14. tension-bearing scaffolding (keratin, lamins)

Define it: high-yield vocabulary

Write a clear definition in your own words for each term.

  1. Plasma membrane
  2. Cytoplasm
  3. Nucleus
  4. Ribosome
  5. Rough endoplasmic reticulum
  6. Smooth endoplasmic reticulum
  7. Golgi apparatus
  8. Mitochondrion
  9. Lysosome
  10. Cytoskeleton

Part 2 of 4 · Anatomy lab

Draw and label

Box A. Generic cell with all organelles

Directions

  1. Draw a large irregular cell outline. Label the plasma membrane.
  2. Draw a round nucleus inside, label it, and add a small darker spot inside labeled Nucleolus. Show the nuclear envelope around it.
  3. Draw rough endoplasmic reticulum (rough ER) as folded sheets near the nucleus, with small dots on its surface (ribosomes). Label both.
  4. Draw smooth endoplasmic reticulum (smooth ER) as folded tubes nearby. Label.
  5. Draw a Golgi apparatus as stacked flattened sacs. Label.
  6. Draw 3 or 4 mitochondria (oval shapes with internal folds). Label one.
  7. Draw 2 lysosomes (small spheres). Label.
  8. Draw a few free ribosomes floating in the cytoplasm. Label.
  9. Add a cytoskeleton: thin lines crossing the cell. Label.
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Box B. A specialized cell type (pick one)

Directions

  1. Pick ONE of these specialized cells and draw it: neuron, skeletal muscle fiber, pancreatic secretory cell, or red blood cell.
  2. Draw it with realistic proportions and shape (e.g., a neuron has long axon and short dendrites; a muscle fiber is long and multinucleate; an RBC is biconcave and has no nucleus).
  3. Label any organelles present. ALSO label any organelles that are absent or unusual (e.g., the RBC has no nucleus and no mitochondria).
  4. Write one sentence explaining how the cell's organelle profile matches its function.
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Your uploaded drawing for Box B. A specialized cell type (pick one)

Structures to label

Label each on your drawing.

  1. Plasma membrane
  2. Nucleus
  3. Nuclear envelope
  4. Nucleolus
  5. Rough endoplasmic reticulum
  6. Smooth endoplasmic reticulum
  7. Ribosome (free)
  8. Ribosome (on rough ER)
  9. Golgi apparatus
  10. Mitochondrion
  11. Lysosome
  12. Peroxisome
  13. Cytoskeleton
  14. Cytoplasm

Part 3 of 4 · Physiology lab

Reason it through

A. Trace a protein from synthesis to secretion

Explain the main idea of this topic.

B. Synthesis

1. A drug poisons all lysosomes in a cell. Predict the consequences over hours to days. Name at least two specific cellular processes that fail.
2. Red blood cells have no nucleus and no mitochondria. Predict (a) their lifespan, (b) their energy source, and (c) one type of damage they cannot repair.
3. A liver cell exposed to chronic alcohol consumption develops a dramatic expansion of its smooth ER. Explain why, in terms of what smooth ER does.

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